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Experimental Research

The experimental unit in the orthopaedic research group focused on entirely new treatment methods which have not yet been approved for use on humans. The primary research areas are improvement of joint prostheses, bone healing and cartliage research. This includes research on surgical methods, implant surfaces, wear particles, growth factors, stem cells and gene therapeutic methods.

The unit has its base in the Orthopaedic Reserach Laboratory at Aarhus University Hospital localed in central Aarhus. The research lab contains biomechanical test facilities, a hard tissue lab, an image diagnostic unit with micro CT scanners and a QCT scanner. A state-of the-art laboratory for the handling of gene-modified material with a new confical microscopy unit.

The experimental unit cooperates widely with other public instituts and private companies both nationally and internationally.


Part of the unit's research is experimental. The unit does research in treatment methods which have shown to be promising in lab experiments and on cell cultures, but have yet to be proven safe or effective for use on humans.

The experimental research takes place at the Clinical Institute at Skejby Hospital on the outskirts of Aarhus. All experimental research projects undertaken by the group are approved by the Danish Ministry of Justice.

Stem Cells

A growing part of the unit's research is concentrated on the research on stem cells. In order to develop new treatment methods for a number of illnesses in joint and muscles, the research focuses on the use of stem cells to regenerate for example cartliage and bone tissue or the response of stem cells in regards to new implants.

The stem cell research takes place at the Laboratory for Molecular Orthopeadics at Aarhus University Hospital. The lab has a modern gene technology cell culture lab, molecular biological techniques, among others Real-Time PCR and advanced microscopy methods fx confocal microscopy. In cooperation with iNANO (Interdiciplinary Nanoscience Centre at the University of Aarhus and Aalborg University) the lab commands high resolution scanning electron equipment and nano-indentation equipment.


Erythropoietin augments bone formation in a rabbit posterolateral spinal fusion model.
Rölfing JHD, Bendtsen M, Jensen J, Stiehler M, Foldager CB, Hellfritzsch MB, Bünger C.
Phenol Red Inhibits Chondrogenic Differentiation and Affects Osteogenic Differentiation of Human Mesenchymal Stem Cells in Vitro.
Lysdahl H, Baatrup A, Nielsen AB, Foldager CB, Bünger C.
Navigated percutaneous lumbosacral interbody fusion: a feasibility study with three-dimensional surgical simulation and cadaveric experiment.
Wang Y, Le DQ, Li H, Wang M, Bünger CE.
Orthopaedic Spinal Research      Aarhus University Hospital      Noerrebrogade 44      Building 1A      8000 Aarhus C      Phone: +45 7846 4133
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